abstract：OBJECTIVE:The aim of this study was to clarify the role of long non-coding RNA (lncRNA) HOXA-AS2 in influencing the proliferative, migratory and apoptotic abilities of human aortic vascular smooth muscle cells (HA-VSMCs) by absorbing microRNA-877-3p (miRNA-877-3p). MATERIALS AND METHODS:HOXA-AS2 level in HA-VSMCs trea...

journal_title：European review for medical and pharmacological sciences

authors： Fan TT,Liu YX,Wang XC,Xu BL,Chen ZC,Lu HA,Zhang M

更新日期：2020-01-01 00:00:00

abstract：INTRODUCTION:To explore the effect of rosiglitazone on myocardial injury in septic rats through the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) pathway. MATERIALS AND METHODS:A total of 60 healthy adult female Sprague-Dawley (SD) rats were randomly divided into 4 groups, namely, group A (sep...

journal_title：European review for medical and pharmacological sciences

authors： Zhang SM,Cai XF,Ma YL,Lu Q

更新日期：2020-01-01 00:00:00

abstract：OBJECTIVE:Glioma is a common aggressive cancer and a major public health problem worldwide, with high incidence, recurrence, and mortality. Circular RNA (circRNA) has been reported to be involved in glioma, but the role of circ_0079593 in glioma is still unclear. MATERIALS AND METHODS:The real-time quantitative polyme...

journal_title：European review for medical and pharmacological sciences

authors： Yang Z,Li C,Fan XY,Liu LJ

更新日期：2020-01-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to investigate the level of circ-0003998 in osteosarcoma tissues and cell lines, and to analyze its relation with prognosis of patients, as well as its effect on biological behaviors of osteosarcoma cells. In addition, the potential mechanism of circ-0003998 in promoting osteosarcoma...

journal_title：European review for medical and pharmacological sciences

authors： Wang L,Du ZG,Huang H,Li FS,Li GS,Xu SN

更新日期：2019-12-01 00:00:00

abstract：OBJECTIVE:Pancreatic carcinoma (PC) is a serious malignancy associated with high morbidity and mortality rates. Previous studies have identified various microRNAs (miRNAs) involved in the development of PC; however, the role of miR-383 still remains unclear. This study investigates the role of miR-383 in the malignant ...

journal_title：European review for medical and pharmacological sciences

authors： Su QL,Zhao HJ,Song CF,Zhao S,Tian ZS,Zhou JJ

更新日期：2019-12-01 00:00:00

abstract：OBJECTIVE:The incidence and death rate of lung cancer has been rising year by year. Non-small cell lung cancer (NSCLC) seriously affects people's health and quality of life. This study was designed to explore the functional role of long-chain non-coding RNA (LncRNA) MIR503HG in the development of NSCLC. PATIENTS AND M...

journal_title：European review for medical and pharmacological sciences

authors： Lin H,Li P,Zhang N,Cao L,Gao YF,Ping F

更新日期：2019-12-01 00:00:00

abstract：OBJECTIVE:Some circular RNAs (circRNAs) have been testified to play crucial roles in the regulation of skin melanoma, including circRNA_0016418 (circ0016418). However, the regulatory mechanism of circ0016418 in skin melanoma is undiscovered. MATERIALS AND METHODS:The RNA expression was examined through quantitative Re...

journal_title：European review for medical and pharmacological sciences

authors： Zou Y,Wang SS,Wang J,Su HL,Xu JH

更新日期：2019-12-01 00:00:00

abstract：OBJECTIVE:Aortic valve stenosis (AS) presents a disease during which there are changes of the aortic valve structure that modify the blood structure of patients. The aim of this study was to improve the effectiveness of differential diagnostics of aortic stenosis and aortic regurgitation using molecular techniques on b...

journal_title：European review for medical and pharmacological sciences

authors： Urban P,Rabajdová M,Špaková I,Sabol F,Mičková H,Lakatosová K,Zavacká M

更新日期：2019-12-01 00:00:00

abstract：OBJECTIVE:Hepatocellular carcinoma (HCC) is one of the most commonly diagnosed cancers globally. LncRNA HLA complex group 11 (HCG11) has been reported to play an oncogenic role in multiple cancers. Nevertheless, the role and regulatory mechanism of HCG11 in HCC are not fully addressed. PATIENTS AND METHODS:The abundan...

journal_title：European review for medical and pharmacological sciences

authors： Li ML,Zhang Y,Ma LT

更新日期：2019-12-01 00:00:00

abstract：OBJECTIVE:Recent researches have proved that long noncoding RNAs (lncRNAs) cover an important role in malignant tumors. Our study showed how lncRNA myocardial infarction-associated transcript (MIAT) functions in the development of Wilms' tumor. PATIENTS AND METHODS:Real Time-quantitative Polymerase Chain Reaction (RT-...

journal_title：European review for medical and pharmacological sciences

authors： Zhao XS,Tao N,Zhang C,Gong CM,Dong CY

更新日期：2019-12-01 00:00:00

abstract：OBJECTIVE:Micro-ribonucleic acids (miRNAs) are involved in the occurrence of various cancers, and the hypoxia-inducible factor 1-α (HIF-1α) is the main regulator of cell proliferation induced by hypoxia. The relationships of miR-199a and HIF-1α expressions with non-small cell lung cancer (NSCLC) remain unclear, so they...

journal_title：European review for medical and pharmacological sciences

authors： Wang LM,Zhang LL,Wang LW,Zhu L,Ma XX

更新日期：2019-12-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to examine the role of lncRNA-differentiation antagonizing non-protein coding RNA (DANCR) and its underlying mechanisms in chondrogenesis, more specifically in synovial fluid-derived mesenchymal stem cell (SFMSCs). MATERIALS AND METHODS:The expression levels of DANCR in SFMSCs were ...

journal_title：European review for medical and pharmacological sciences

authors： Fang P,Zhang LX,Hu Y,Zhang L,Zhou LW

更新日期：2019-12-01 00:00:00

abstract：OBJECTIVE:To explore the influence of butorphanol on myocardial ischemia/reperfusion (I/R) injury in rats through the mitogen-activated protein kinase (MAPK) signaling pathway. MATERIALS AND METHODS:The I/R model in Sprague-Dawley rats was established. The rats were randomly divided into normal group (n=20), myocardia...

journal_title：European review for medical and pharmacological sciences

authors： Wang H,Wang JL,Ren HW,He WF,Sun M

更新日期：2019-12-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to investigate the effect of microRNA-214-5p (miR-214-5p) on spinal cord injury (SCI) and to explore the mechanism of action in pathophysiological relevance. MATERIALS AND METHODS:The model of SCI was successfully established in rats aged 6-8 weeks. The levels of the locomotor funct...

journal_title：European review for medical and pharmacological sciences

authors： A JC,Li ZY,Long QF,Wang DY,Zhao HS,Jia SL,Zhang WH

更新日期：2019-11-01 00:00:00

abstract：OBJECTIVE:Gallbladder carcinoma is a malignant tumor in the bile duct with poor prognosis. Although aberrant expression of miR-335 has been reported in the tumor tissues of gallbladder carcinoma, the biological role of miR-335 was still largely unknown. This study was intended to explore the role of miR-335 in the prog...

journal_title：European review for medical and pharmacological sciences

authors： Wang W,Chen LC,Qian JY,Zhang Q

更新日期：2019-11-01 00:00:00

abstract：OBJECTIVE:Nasopharyngeal carcinoma (NPC) is one of the most ordinary malignant tumors. Recent studies have revealed that circular RNAs play an important role in the progression of tumorigenesis. This study aims to identify how circular RNA_LARP4 functions in the progression of NPC. PATIENTS AND METHODS:We performed Re...

journal_title：European review for medical and pharmacological sciences

authors： Pan JY,Bao XL,Zhu K

更新日期：2019-11-01 00:00:00

abstract：OBJECTIVE:To uncover the role of UPF1 in alleviating the progression of glioma via targeting long non-coding RNA (lncRNA) CYTOR and underlying mechanism. PATIENTS AND METHODS:A total of 30 glioma tissues surgically resected from glioma patients and 30 brain tissues were collected from brain trauma patients undergoing ...

journal_title：European review for medical and pharmacological sciences

authors： Zou SF,Yang XY,Li JB,Ding H,Bao YY,Xu J

更新日期：2019-11-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to evaluate the influence of long non-coding ribonucleic acid (lncRNA) antisense non-coding RNA in the INK4 locus (ANRIL) on neuronal apoptosis in rats with cerebral infarction (CI), and to further explore the underlying mechanism of lncRNA ANRIL in the occurrence and development of ...

journal_title：European review for medical and pharmacological sciences

authors： Zhao JH,Wang B,Wang XH,Wang JR,Xu CW

更新日期：2019-11-01 00:00:00

abstract：OBJECTIVE:To elucidate whether long non-coding RNA (lncRNA) Bmncr could inhibit RANML-induced osteoclast differentiation, thus alleviating the progression of osteoporosis. MATERIALS AND METHODS:Expression level of lncRNA Bmncr at different stages of osteoclast differentiation was detected by quantitative Real Time-Pol...

journal_title：European review for medical and pharmacological sciences

authors： Chen RS,Zhang XB,Zhu XT,Wang CS

更新日期：2019-11-01 00:00:00

abstract：OBJECTIVE:The carcinogenic effects of circular RNA circ-PRKCI have been recognized in a variety of malignancies. However, the exact biological function of circ-PRKCI in gastric cancer has not been fully elucidated. Therefore, the aim of this study was to explore the expression of circ-PRKCI in gastric cancer (GC) and t...

journal_title：European review for medical and pharmacological sciences

authors： Wu L,Li Y,Xu XM,Zhu X

更新日期：2019-11-01 00:00:00

abstract：OBJECTIVE:The purpose of this study was to investigate whether microRNA-135 plays a role in the malignant progression of gastric cancer (GC) by regulating SMAD2 and its underlying mechanism. PATIENTS AND METHODS:Quantitative Real Time-Polymerase Chain Reaction (qRT-PCR) was performed to examine microRNA-135 expression...

journal_title：European review for medical and pharmacological sciences

authors： He Y,Wu L,Dai Y,Li J,Liu S

更新日期：2019-11-01 00:00:00

abstract：OBJECTIVE:This study was designed to investigate whether microRNA-130-5p could promote the progression and metastasis of lung cancer by targeting enhancer of zeste homolog 2 (EZH2). PATIENTS AND METHODS:The level of microRNA-130-5p was examined in the tumor tissues and paracancerous tissues of lung adenocarcinoma pati...

journal_title：European review for medical and pharmacological sciences

authors： Zhang G,Wu YJ,Yan F

更新日期：2019-11-01 00:00:00

abstract：OBJECTIVE:To explore the correlations between the degree of coronary artery stenosis with blood lipid, C-reactive protein (CRP), homocysteine (Hcy), gamma-glutamyl transpeptidase (GGT), soluble cluster determinant 36 (sCD36), and fibrinogen (Fib) levels in elderly patients with coronary heart disease. PATIENTS AND MET...

journal_title：European review for medical and pharmacological sciences

authors： Han K,Lu Q,Zhu WJ,Wang TZ,Du Y,Bai L

更新日期：2019-11-01 00:00:00

abstract：OBJECTIVE:Mesenchymal stem cells (MSCs) induce allograft immune tolerance, but low efficacy severely limits their wide application. In this work, Netrin-1 was used to maintain MSC function in an IR environment to study its role in the immune tolerance induction of the allograft. MATERIALS AND METHODS:The experiments w...

journal_title：European review for medical and pharmacological sciences

authors： Liu LP,Chen W,Fan Y,Qi BY,Wang Z,Shi BY

更新日期：2019-10-01 00:00:00

abstract：OBJECTIVE:DJ-1 is a negative regulator of PTEN and plays a role in tumorigenesis. Abnormal miR-203 expression is associated with pancreatic cancer. Bioinformatics analysis showed a targeted relationship between miR-203 and DJ-1 3'-UTR. This study investigated whether miR-203 regulates DJ-1 expression and its role in pa...

journal_title：European review for medical and pharmacological sciences

authors： Du SL,Xu LY,Gao P,Liu QS,Lu FF,Mo ZH,Fan ZZ,Cheng XL,Dong ZH

更新日期：2019-10-01 00:00:00

abstract：OBJECTIVE:To explore the influence of micro ribonucleic acid (miR)-101 on breast cancer cell proliferation and apoptosis via nuclear factor (erythroid-derived 2)-like 2 (Nrf2) signaling pathway. MATERIALS AND METHODS:All MCF-7 cells were divided into 3 groups, namely control group, miR-101 mimic group (the cells were ...

journal_title：European review for medical and pharmacological sciences

authors： Yi J,Huang WZ,Wen YQ,Yi YC

更新日期：2019-10-01 00:00:00

abstract：OBJECTIVE:To explore the mechanism microRNA-378 in smoking-induced airway inflammation and mucus hypersecretion. MATERIALS AND METHODS:Human bronchial epithelial (HBE) cells were treated with cigarette smoke extract (CSE) to construct the in vitro COPD model. Expression levels of microRNA-378, inflammatory factors and...

journal_title：European review for medical and pharmacological sciences

authors： Zhang JL,Yang CQ,Deng F

更新日期：2019-10-01 00:00:00

abstract：OBJECTIVE:To explore the effects of lamivudine on cell proliferation of liver cancer and expressions of HBsAg, HBeAg, and MMP-9 in hepatoma cells. MATERIALS AND METHODS:In the intervention group, HepG2.2.15 cells were cultured with lamivudine at 100, 200, and 300 μmol/L for 24 hours, 48 hours, and 72 hours. In the con...

journal_title：European review for medical and pharmacological sciences

authors： Zhang J,Yu H,Sun FY,Li J,Li DM,Sun CH

更新日期：2019-10-01 00:00:00

abstract：OBJECTIVE:To clarify the role of microRNA-183-5p in the malignant progression of osteosarcoma (OS) and the potential mechanism. PATIENTS AND METHODS:Relative level of microRNA-183-5p in 40 paired OS tissues and matched normal tissues was determined by quantitative Real Time-Polymerase Chain Reaction (qRT-PCR). Correla...

journal_title：European review for medical and pharmacological sciences

authors： Shao JH,Yuan S,Qian QR,Zhu J

更新日期：2019-10-01 00:00:00

abstract：OBJECTIVE:Prostate cancer (PC) is one of the most ordinary malignant cancers. Recent researches have proved that long noncoding RNAs (lncRNAs) act as an important role in cancers. Our study aims to explore the function of lncRNA CASC15 in the tumor metastasis of PC. PATIENTS AND METHODS:Real Time-quantitative Polymera...

journal_title：European review for medical and pharmacological sciences

authors： Zhang C,Wang GX,Fu B,Zhou XC,Li Y,Li YY

更新日期：2019-10-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to detect the relationship between long-chain non-coding RNA (lncRNA) NEAT1 and microRNA-1224 (miR-1224) in lung cancer and to explore its underlying mechanism. MATERIALS AND METHODS:The expression levels of lncRNA NEAT1 and miR-1224 in lung cancer tissues and cells were detected by...

journal_title：European review for medical and pharmacological sciences

authors： Yu PF,Wang Y,Lv W,Kou D,Hu HL,Guo SS,Zhao YJ

更新日期：2019-10-01 00:00:00

abstract：OBJECTIVE:To analyze the different influence of body position on wireless high-resolution anorectal manometry parameters and in classification for chronic constipation patients. PATIENTS AND METHODS:Fifty consecutive patients with chronic constipation and 20 healthy volunteers were included in this study, all of whom ...

journal_title：European review for medical and pharmacological sciences

authors： Su H,Peng LH,Sun G,Yang YS,Wu J,Jiang GJ,Ge H

更新日期：2019-10-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to investigate the effect of long non-coding ribonucleic acid (lncRNA) growth arrest specific 5 (GAS5) on acute myocardial infarction (AMI) model rats and to explore its regulatory mechanism. MATERIALS AND METHODS:The rat model of AMI was established by subcutaneous injection of iso...

journal_title：European review for medical and pharmacological sciences

authors： Zhang JC,Xia L,Jiang Y,Wu DQ,Liu SC,Zhou XN,Zhang FX

更新日期：2019-10-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to investigate the effect of ulinastatin (UTI) on myocardial ischemia-reperfusion injury (MIRI) through the c-Jun N-terminal kinase (JNK) signaling pathway and p38 mitogen-activated protein kinase (MAPK) signaling pathway. MATERIALS AND METHODS:Healthy adult male Sprague-Dawley (SD)...

journal_title：European review for medical and pharmacological sciences

authors： Yang ZH,Lu YJ,Gu KP,Xiang ZY,Huang HM

更新日期：2019-10-01 00:00:00

abstract：OBJECTIVE:To elucidate the function of miRNA-138-5p in the early diabetic retinopathy (DR) and the potential mechanism. MATERIALS AND METHODS:DR model in rats was first established by streptozotocin (STZ) injection. MiRNA-138-5p expression in rat retinal tissues was determined by quantitative Real Time-Polymerase Chai...

journal_title：European review for medical and pharmacological sciences

authors： Bao XY,Cao J

更新日期：2019-09-01 00:00:00

abstract：OBJECTIVE:The long non-coding RNA, FAM83H antisense RNA 1 (head to head) (FAM83H-AS1), has been reported to function as an oncogene in some types of cancer. However, the role of lncRNA FAM83H-AS1 in hepatocellular carcinoma (HCC) still remains unknown. The present work aims to explore the effect of lncRNA FAM83H-AS1 on...

journal_title：European review for medical and pharmacological sciences

authors： Ma YK,Shen TH,Yang XY

更新日期：2019-09-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to identify the role of long non-coding RNA (lncRNA) NBR2 in non-small-cell lung cancer (NSCLC) and its possible molecular mechanisms. PATIENTS AND METHODS:The quantitative Real Time-Polymerase Chain Reaction (qRT-PCR) was used to explore lncRNA NBR2 expression in NSCLC cells and ti...

journal_title：European review for medical and pharmacological sciences

authors： Gao YP,Li Y,Li HJ,Zhao B

更新日期：2019-09-01 00:00:00

abstract：OBJECTIVE:To explore the influence and the underlying mechanism of micro-ribonucleic acid (miR)-34a on cerebral neuronal apoptosis in rats with cerebral ischemia-reperfusion (CIR). MATERIALS AND METHODS:60 adult male Wistar rats were randomly divided into 3 groups: Sham group, CIR group and miR-34a knockdown group. Th...

journal_title：European review for medical and pharmacological sciences

authors： Wang SP,Wang D,Li HX,Liu L,Duan XH

更新日期：2019-09-01 00:00:00

abstract：OBJECTIVE:Samter's triad is the combination of asthma, aspirin sensitization, and nasal polyposis. Few data are available on the use of omalizumab in this disease. The study aimed to describe the impact of omalizumab on clinical and functional parameters and the quality of life of a series of patients with Samter's tri...

journal_title：European review for medical and pharmacological sciences

authors： Cameli P,Perruzza M,Salvini M,Fui A,Cekorja B,Refini RM,Sestini P,Bargagli E

更新日期：2019-09-01 00:00:00

abstract：OBJECTIVE:MiR-199 expression is associated with liver cancer. Bioinformatics analysis revealed that miR-199 has a complementary binding site to the 3'-UTR region of Snail mRNA. This study investigated whether miR-199 plays a role in regulating Snail expression and affecting epithelial-mesenchymal transition (EMT) and i...

journal_title：European review for medical and pharmacological sciences

authors： Zhang HY,Li CH,Wang XC,Luo YQ,Cao XD,Chen JJ

更新日期：2019-09-01 00:00:00